Uk Sepsis Trust Clinical Tools

The UK Sepsis trust have created a number of free to use, clincal tools to support a standard approach to spotting and managing sepsis.

Access the tools here

 

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NICE Guideline (NG51)- Sepsis: recognition, diagnosis and early management

Updated in September 2017 NICE have produced guidelines on sepsis including:
•Recommendations on identifying and assessing people with suspected sepsis, risk factors and risk stratification for sepsis and managing suspected sepsis in acute hospital settings and out of hospital
•Tools and resources to help put the guidance into practice
•Information for the public.

To view full guideline click here

Sepsis Articles Published in November-December

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  1. Biochemical-immunological hybrid biosensor based on two-dimensional chromatography for on-site sepsis diagnosis.

Author(s): Kim, Seung-Wan; Cho, Il-Hoon; Lim, Guei-Sam; Park, Gi-Na; Paek, Se-Hwan

Source: Biosensors & bioelectronics; Dec 2017; vol. 98 ; p. 7-14

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Plasma lactoferrin levels in newborn preterm infants with sepsis.

Author(s): Decembrino, Lidia; DeAmici, Mara; De Silvestri, Annalisa; Manzoni, Paolo; Paolillo, Piermichele; Stronati, Mauro

Source: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians; Dec 2017; vol. 30 (no. 23); p. 2890-2893

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Cholangitis Lenta: A Clinicopathologic Study of 28 Cases.

Author(s): Torous, Vanda F; De La Cruz, A Laura; Naini, Bita V; Wang, Hanlin L

Source: The American journal of surgical pathology; Dec 2017; vol. 41 (no. 12); p. 1607-1617

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Gastric perforation after duodenopancreatectomy.

Author(s): Bäcker, Henrik; Beeres, Frank Jp; Rossi, Marco; Scheiwiller, Andreas

Source: Medical mycology case reports; Dec 2017; vol. 18 ; p. 21-23

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. The Physiology of Early Goal-Directed Therapy for Sepsis.

Author(s): Lief, Lindsay; Arbo, John; Berlin, David A

Source: Journal of intensive care medicine; Dec 2017; vol. 32 (no. 10); p. 567-573

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. 6. Nitrite administration improves sepsis-induced myocardial and mitochondrial dysfunction by modulating stress signal responses.

Author(s): Kawaguchi, Ryoichi; Hirata, Naoyuki; Tokinaga, Yasuyuki; Hayashi, Shunsuke; Inoue, Shigeaki; Watanabe, Nobuo; Yamakage, Michiaki

Source: Journal of anesthesia; Dec 2017; vol. 31 (no. 6); p. 885-894

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Predictive value of procalcitonin for diagnosis of infections in patients with chronic kidney disease: a comparison with traditional inflammatory markers C-reactive protein, white blood cell count, and neutrophil percentage.

Author(s): Sun, Yanbei; Jiang, Lijuan; Shao, Xiaonan

Source: International urology and nephrology; Dec 2017; vol. 49 (no. 12); p. 2205-2216

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Sepsis prediction in critically ill patients by platelet activation markers on ICU admission: a prospective pilot study.

Author(s): Layios, Nathalie; Delierneux, Céline; Hego, Alexandre; Huart, Justine; Gosset, Christian; Lecut, Christelle; Maes, Nathalie; Geurts, Pierre; Joly, Arnaud; Lancellotti, Patrizio; Albert, Adelin; Damas, Pierre; Gothot, André; Oury, Cécile

Source: Intensive care medicine experimental; Dec 2017; vol. 5 (no. 1); p. 32

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Increased glucocorticoid receptor expression in sepsis is related to heat shock proteins, cytokines, and cortisol and is associated with increased mortality.

Author(s): Vardas, Konstantinos; Ilia, Stavroula; Sertedaki, Amalia; Charmandari, Evangelia; Briassouli, Efrossini; Goukos, Dimitris; Apostolou, Kleovoulos; Psarra, Katerina; Botoula, Efthimia; Tsagarakis, Stylianos; Magira, Eleni; Routsi, Christina; Stratakis, Constantine A; Nanas, Serafim; Briassoulis, George

Source: Intensive care medicine experimental; Dec 2017; vol. 5 (no. 1); p. 10

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Baseline thrombospondin-1 concentrations are not associated with mortality in septic patients: a single-center cohort study on the intensive care unit.

Author(s): van der Wekken, Ruben J; Kemperman, Hans; Roest, Mark; de Lange, Dylan W

Source: Intensive care medicine experimental; Dec 2017; vol. 5 (no. 1); p. 7

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Erratum to: Heparin-binding protein is important for vascular leak in sepsis.

Author(s): Bentzer, Peter; Fisher, Jane; Kong, HyeJin Julia; Mörgelin, Mattias; Boyd, John H; Walley, Keith R; Russell, James A; Linder, Adam

Source: Intensive care medicine experimental; Dec 2017; vol. 5 (no. 1); p. 6

Publication Date: Dec 2017

Publication Type(s): Published Erratum

 

  1. Soluble Toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission.

Author(s): Holst, Benjamin; Szakmany, Tamas; Raby, Anne-Catherine; Hamlyn, Vincent; Durno, Kimberley; Hall, Judith E; Labéta, Mario O

Source: Intensive care medicine experimental; Dec 2017; vol. 5 (no. 1); p. 2

Publication Date: Dec 2017

Publication Type(s): Letter

 

  1. Sepsis in Older Adults.

Author(s): Rowe, Theresa A; McKoy, June M

Source: Infectious disease clinics of North America; Dec 2017; vol. 31 (no. 4); p. 731-742

Publication Date: Dec 2017

Publication Type(s): Journal Article Review

 

  1. Neutropenic Fever.

Author(s): White, Lindsey; Ybarra, Michael

Source: Hematology/oncology clinics of North America; Dec 2017; vol. 31 (no. 6); p. 981-993

Publication Date: Dec 2017

Publication Type(s): Journal Article Review

 

  1. Intermediate-term and long-term mortality among acute medical patients hospitalized with community-acquired sepsis: a population-based study.

Author(s): Henriksen, Daniel P; Pottegård, Anton; Laursen, Christian B; Jensen, Thøger G; Hallas, Jesper; Pedersen, Court; Lassen, Annmarie T

Source: European journal of emergency medicine : official journal of the European Society for Emergency Medicine; Dec 2017; vol. 24 (no. 6); p. 404-410

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Septic shock resuscitation in the first hour.

Author(s): Simpson, Nicholas; Lamontagne, Francois; Shankar-Hari, Manu

Source: Current opinion in critical care; Dec 2017; vol. 23 (no. 6); p. 561-566

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Assessment of sepsis-induced immunosuppression at ICU discharge and 6 months after ICU discharge.

Author(s): Zorio, Violette; Venet, Fabienne; Delwarde, Benjamin; Floccard, Bernard; Marcotte, Guillaume; Textoris, Julien; Monneret, Guillaume; Rimmelé, Thomas

Source: Annals of intensive care; Dec 2017; vol. 7 (no. 1); p. 80

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Red blood cell transfusion in the resuscitation of septic patients with hematological malignancies.

Author(s): Mirouse, Adrien; Resche-Rigon, Matthieu; Lemiale, Virginie; Mokart, Djamel; Kouatchet, Achille; Mayaux, Julien; Vincent, François; Nyunga, Martine; Bruneel, Fabrice; Rabbat, Antoine; Lebert, Christine; Perez, Pierre; Renault, Anne; Meert, Anne-Pascale; Benoit, Dominique; Hamidfar, Rebecca; Jourdain, Mercé; Darmon, Michaël; Azoulay, Elie; Pène, Frédéric; Groupe de Recherche sur la Réanimation Respiratoire en Onco-Hématologie (Grrr-OH)

Source: Annals of intensive care; Dec 2017; vol. 7 (no. 1); p. 62

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Low HDL levels in sepsis versus trauma patients in intensive care unit.

Author(s): Tanaka, Sébastien; Labreuche, Julien; Drumez, Elodie; Harrois, Anatole; Hamada, Sophie; Vigué, Bernard; Couret, David; Duranteau, Jacques; Meilhac, Olivier

Source: Annals of intensive care; Dec 2017; vol. 7 (no. 1); p. 60

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Omega-3 supplementation in patients with sepsis: a systematic review and meta-analysis of randomized trials.

Author(s): Lu, Clara; Sharma, Sunjay; McIntyre, Lauralyn; Rhodes, Andrew; Evans, Laura; Almenawer, Saleh; Leduc, Lori; Angus, Derek C; Alhazzani, Waleed

Source: Annals of intensive care; Dec 2017; vol. 7 (no. 1); p. 58

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. The impact of a multifaceted intervention including sepsis electronic alert system and sepsis response team on the outcomes of patients with sepsis and septic shock.

Author(s): Arabi, Yaseen M; Al-Dorzi, Hasan M; Alamry, Ahmed; Hijazi, Ra’ed; Alsolamy, Sami; Al Salamah, Majid; Tamim, Hani M; Al-Qahtani, Saad; Al-Dawood, Abdulaziz; Marini, Abdellatif M; Al Ehnidi, Fatimah H; Mundekkadan, Shihab; Matroud, Amal; Mohamed, Mohamed S; Taher, Saadi

Source: Annals of intensive care; Dec 2017; vol. 7 (no. 1); p. 57

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure.

Author(s): Martin-Loeches, Ignacio; Muriel-Bombín, Arturo; Ferrer, Ricard; Artigas, Antonio; Sole-Violan, Jordi; Lorente, Leonardo; Andaluz-Ojeda, David; Prina-Mello, Adriele; Herrán-Monge, Ruben; Suberviola, Borja; Rodriguez-Fernandez, Ana; Merino, Pedro; Loza, Ana M; Garcia-Olivares, Pablo; Anton, Eduardo; Tamayo, Eduardo; Trapiello, Wysali; Blanco, Jesús; Bermejo-Martin, Jesús F; GRECIA group

Source: Annals of intensive care; Dec 2017; vol. 7 (no. 1); p. 44

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Sepsis risk factors in infants with congenital diaphragmatic hernia.

Author(s): Levy, Michaël; Le Sache, Nolwenn; Mokhtari, Mostafa; Fagherazzi, Guy; Cuzon, Gaelle; Bueno, Benjamin; Fouquet, Virginie; Benachi, Alexandra; Eleni Dit Trolli, Sergio; Tissieres, Pierre

Source: Annals of intensive care; Dec 2017; vol. 7 (no. 1); p. 32

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. A hypoperfusion context may aid to interpret hyperlactatemia in sepsis-3 septic shock patients: a proof-of-concept study.

Author(s): Alegría, Leyla; Vera, Magdalena; Dreyse, Jorge; Castro, Ricardo; Carpio, David; Henriquez, Carolina; Gajardo, Daniela; Bravo, Sebastian; Araneda, Felipe; Kattan, Eduardo; Torres, Pedro; Ospina-Tascón, Gustavo; Teboul, Jean-Louis; Bakker, Jan; Hernández, Glenn

Source: Annals of intensive care; Dec 2017; vol. 7 (no. 1); p. 29

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Multi-marker approach using procalcitonin, presepsin, galectin-3, and soluble suppression of tumorigenicity 2 for the prediction of mortality in sepsis.

Author(s): Kim, Hanah; Hur, Mina; Moon, Hee-Won; Yun, Yeo-Min; Di Somma, Salvatore; GREAT Network

Source: Annals of intensive care; Dec 2017; vol. 7 (no. 1); p. 27

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. IL-6 rs1800795 polymorphism is associated with septic shock-related death in patients who underwent major surgery: a preliminary retrospective study.

Author(s): Jiménez-Sousa, Maria Angeles; Medrano, Luz Maria; Liu, Pilar; Fernández-Rodríguez, Amanda; Almansa, Raquel; Gomez-Sanchez, Esther; Ortega, Alicia; Heredia-Rodríguez, María; Gómez-Pesquera, Estefanía; Tamayo, Eduardo; Resino, Salvador

Source: Annals of intensive care; Dec 2017; vol. 7 (no. 1); p. 22

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Epidemiology of sepsis in Catalonia: analysis of incidence and outcomes in a European setting.

Author(s): Yébenes, Juan Carlos; Ruiz-Rodriguez, Juan Carlos; Ferrer, Ricard; Clèries, Montserrat; Bosch, Anna; Lorencio, Carol; Rodriguez, Alejandro; Nuvials, Xavier; Martin-Loeches, Ignacio; Artigas, Antoni; SOCMIC (Catalonian Critical Care Society) Sepsis Working Group

Source: Annals of intensive care; Dec 2017; vol. 7 (no. 1); p. 19

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Associations among left ventricular systolic function, tachycardia, and cardiac preload in septic patients.

Author(s): Lanspa, Michael J; Shahul, Sajid; Hersh, Andrew; Wilson, Emily L; Olsen, Troy D; Hirshberg, Eliotte L; Grissom, Colin K; Brown, Samuel M

Source: Annals of intensive care; Dec 2017; vol. 7 (no. 1); p. 17

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Superior accuracy of mid-regional proadrenomedullin for mortality prediction in sepsis with varying levels of illness severity.

Author(s): Andaluz-Ojeda, David; Nguyen, H Bryant; Meunier-Beillard, Nicolas; Cicuéndez, Ramón; Quenot, Jean-Pierre; Calvo, Dolores; Dargent, Auguste; Zarca, Esther; Andrés, Cristina; Nogales, Leonor; Eiros, Jose María; Tamayo, Eduardo; Gandía, Francisco; Bermejo-Martín, Jesús F; Charles, Pierre Emmanuel

Source: Annals of intensive care; Dec 2017; vol. 7 (no. 1); p. 15

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Early risk factors and the role of fluid administration in developing acute respiratory distress syndrome in septic patients.

Author(s): Seethala, Raghu R; Hou, Peter C; Aisiku, Imoigele P; Frendl, Gyorgy; Park, Pauline K; Mikkelsen, Mark E; Chang, Steven Y; Gajic, Ognjen; Sevransky, Jonathan

Source: Annals of intensive care; Dec 2017; vol. 7 (no. 1); p. 11

Publication Date: Dec 2017

Publication Type(s): Journal Article

 

  1. Impact of transfusion on patients with sepsis admitted in intensive care unit: a systematic review and meta-analysis.

Author(s): Dupuis, Claire; Sonneville, Romain; Adrie, Christophe; Gros, Antoine; Darmon, Michael; Bouadma, Lila; Timsit, Jean-François

Source: Annals of intensive care; Dec 2017; vol. 7 (no. 1); p. 5

Publication Date: Dec 2017

Publication Type(s): Journal Article Review

 

  1. Fluid resuscitation in human sepsis: Time to rewrite history?

Author(s): Byrne, Liam; Van Haren, Frank

Source: Annals of intensive care; Dec 2017; vol. 7 (no. 1); p. 4

Publication Date: Dec 2017

Publication Type(s): Journal Article Review

 

  1. Sepsis biomarkers reprofiling to predict stroke-associated infections.

Author(s): Bustamante, Alejandro; García-Berrocoso, Teresa; Penalba, Anna; Giralt, Dolors; Simats, Alba; Muchada, Marian; Zapata, Elena; Rubiera, Marta; Montaner, Joan

Source: Journal of neuroimmunology; Nov 2017; vol. 312 ; p. 19-23

Publication Date: Nov 2017

Publication Type(s): Journal Article

 

  1. Improving door-to-needle times for patients with suspected neutropenic sepsis.

Author(s): Wild, Tracy

Source: Emergency nurse : the journal of the RCN Accident and Emergency Nursing Association; Nov 2017; vol. 25 (no. 7); p. 24-30

Publication Date: Nov 2017

Publication Type(s): Journal Article

 

  1. Lactate improves SAPS 3 prognostication.

Author(s): Andersson, P; Frigyesi, A

Source: Acta anaesthesiologica Scandinavica; Nov 2017

Publication Date: Nov 2017

Publication Type(s): Journal Article

 

Advice on How to Recognise and Understand Sepsis for Student Nurses

Student Editor of the Nursing times Alisha Poole writes about how to spot Sepsis aimed at Student Nurses.

Read full article by clicking the link below

https://www.nursingtimes.net/students/why-is-it-so-important-for-student-nurses-to-recognise-and-understand-sepsis/7021878.article

(You may need to sign up for free guest access)

NHS England Produces Sepsis Guidance Implementation Advice for Adults

NHS England has worked with NICE using their guidance and with a group of sepsis experts and the UK Sepsis Trust to produce an operational definition that fits with use of the National Early Warning Score in assessing patients who are acutely unwell (Sepsis guidance implementation advice for adults – NHS England)

 

Access full document here

London Scientists unveil new sepsis detection device

Scientists at the Imperial College of Science, Technology and Medicine have developed a device that will detect potentially deadly, infectious diseases within hours of taking blood samples.

The device may help to save lives by reducing the time taken by current lab tests.

Read the full news story from The Evening Standard