Quality Improvement Initiative for Severe Sepsis and Septic Shock Reduces 90-Day Mortality: A 7.5-Year Observational Study*

Critical Care Medicine 45(2), February 2017, p 241–252

This study investigates the impact of a quality improvement initiative for severe sepsis and septic shock focused on the resuscitation bundle on 90-day mortality. Furthermore, effects on compliance rates for antiinfective therapy within the recommended 1-hour interval are evaluated. The article concludes, that the continuous quality improvement initiative focused on the resuscitation bundle was associated with increased compliance and a persistent reduction in 90-day mortality over a 7.5-year period. Based on the observational study design, a causal relationship cannot be proven, and respective limitations need to be considered.

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Sepsis-3 Criteria for In-Hospital Mortality: What’s the Prognostic Accuracy?

ESICM -European Society for Intensive Care Medicine

The author reviews the article by Freund at al Prognostic Accuracy of Sepsis-3 Criteria for In-Hospital Mortality Among Patients With Suspected Infection Presenting to the Emergency Department (JAMA Jan 2017:301-308 2017) examining the use of Sequential Organ Failure Assessment (SOFA) and quick SOFA (qSOFA) in the early diagnosis of sepsis in the Emergency Department or on the ward.

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World Health Organization – Statement on Maternal Sepsis

This statement reports on the third most common direct cause of maternal mortality, maternal sepsis, received less attention, research and programming. Undetected or poorly managed maternal infections can lead to sepsis, death or disability for the mother and increased likelihood of early neonatal infection and other adverse outcomes.

Follow this link for the full statement

Date: February 2017